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Dysregulation of SIRT3 SUMOylation Confers AML Chemoresistance via Controlling HES1-Dependent Fatty Acid Oxidation

Sirtuin 3 (SIRT3) deacetylase is a key regulator for chemoresistance in acute myeloid leukemia (AML) cells due to its capability of modulating mitochondrial metabolism and reactive oxygen species (ROS). SIRT3 is de-SUMOylated by SUMO-specific peptidase 1 (SENP1), which enhances its deacetylase activ...

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Detalles Bibliográficos
Autores principales:	Zhang, Yirong, Shen, Yajie, Wei, Weiqing, Wang, Wenhan, Jiang, Daiji, Ren, Yizhuo, Peng, Zijing, Fan, Qiuju, Cheng, Jinke, Ma, Jiao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9368767/ https://www.ncbi.nlm.nih.gov/pubmed/35955415 http://dx.doi.org/10.3390/ijms23158282

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