Inactivation of Target RNA Cleavage of a III-B CRISPR-Cas System Induces Robust Autoimmunity in Saccharolobus islandicus

Type III CRISPR-Cas systems show the target (tg)RNA-activated indiscriminate DNA cleavage and synthesis of oligoadenylates (cOA) and a secondary signal that activates downstream nuclease effectors to exert indiscriminate RNA/DNA cleavage, and both activities are regulated in a spatiotemporal fashion...

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Detalles Bibliográficos
Autores principales: Zhang, Yan, Lin, Jinzhong, Tian, Xuhui, Wang, Yuan, Zhao, Ruiliang, Wu, Chenwei, Wang, Xiaoning, Zhao, Pengpeng, Bi, Xiaonan, Yu, Zhenxiao, Han, Wenyuan, Peng, Nan, Liang, Yun Xiang, She, Qunxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9368842/
https://www.ncbi.nlm.nih.gov/pubmed/35955649
http://dx.doi.org/10.3390/ijms23158515

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9368842/
https://www.ncbi.nlm.nih.gov/pubmed/35955649
http://dx.doi.org/10.3390/ijms23158515

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