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Inactivation of Target RNA Cleavage of a III-B CRISPR-Cas System Induces Robust Autoimmunity in Saccharolobus islandicus
Type III CRISPR-Cas systems show the target (tg)RNA-activated indiscriminate DNA cleavage and synthesis of oligoadenylates (cOA) and a secondary signal that activates downstream nuclease effectors to exert indiscriminate RNA/DNA cleavage, and both activities are regulated in a spatiotemporal fashion...
Autores principales: | Zhang, Yan, Lin, Jinzhong, Tian, Xuhui, Wang, Yuan, Zhao, Ruiliang, Wu, Chenwei, Wang, Xiaoning, Zhao, Pengpeng, Bi, Xiaonan, Yu, Zhenxiao, Han, Wenyuan, Peng, Nan, Liang, Yun Xiang, She, Qunxin |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9368842/ https://www.ncbi.nlm.nih.gov/pubmed/35955649 http://dx.doi.org/10.3390/ijms23158515 |
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