Design and Synthesis of Benzene Homologues Tethered with 1,2,4-Triazole and 1,3,4-Thiadiazole Motifs Revealing Dual MCF-7/HepG2 Cytotoxic Activity with Prominent Selectivity via Histone Demethylase LSD1 Inhibitory Effect

In this study, an efficient multistep synthesis of novel aromatic tricyclic hybrids incorporating different biological active moieties, such as 1,3,4-thiadiazole and 1,2,4-triazole, was reported. These target scaffolds are characterized by having terminal lipophilic or hydrophilic parts, and their s...

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Detalles Bibliográficos
Autores principales: Alsehli, Mosa, Aljuhani, Ateyatallah, Ihmaid, Saleh K., El-Messery, Shahenda M., Othman, Dina I. A., El-Sayed, Abdel-Aziz A. A., Ahmed, Hany E. A., Rezki, Nadjet, Aouad, Mohamed R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369007/
https://www.ncbi.nlm.nih.gov/pubmed/35955929
http://dx.doi.org/10.3390/ijms23158796

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369007/
https://www.ncbi.nlm.nih.gov/pubmed/35955929
http://dx.doi.org/10.3390/ijms23158796

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