A Novel Antibody Targeting the Second Extracellular Loop of the Serotonin 5-HT2A Receptor Inhibits Platelet Function

Serotonin (5-hydroxytriptamine or 5-HT) is known to be a weak platelet agonist, and is involved in thrombus formation. While 5-HT cannot induce platelet aggregation on its own, when secreted from the alpha granules, it binds to its G-protein Coupled Receptor (GPCR; i.e., 5HT(2A)R), thereby acting to...

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Detalles Bibliográficos
Autores principales: Ramirez, Jean E. M., Alarabi, Ahmed B., Khasawneh, Fadi T., Alshbool, Fatima Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369033/
https://www.ncbi.nlm.nih.gov/pubmed/35955928
http://dx.doi.org/10.3390/ijms23158794

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369033/
https://www.ncbi.nlm.nih.gov/pubmed/35955928
http://dx.doi.org/10.3390/ijms23158794

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