Identification of Novel Inhibitors Targeting SGK1 via Ensemble-Based Virtual Screening Method, Biological Evaluation and Molecular Dynamics Simulation

Serum and glucocorticoid-regulated kinase 1 (SGK1), as a serine threonine protein kinase of the AGC family, regulates different enzymes, transcription factors, ion channels, transporters, and cell proliferation and apoptosis. Inhibition of SGK1 is considered as a valuable approach for the treatment...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Hui, Shen, Chen, Zhang, Hong-Rui, Qi, Hua-Zhao, Hu, Mei-Ling, Luo, Qing-Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369041/
https://www.ncbi.nlm.nih.gov/pubmed/35955763
http://dx.doi.org/10.3390/ijms23158635

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369041/
https://www.ncbi.nlm.nih.gov/pubmed/35955763
http://dx.doi.org/10.3390/ijms23158635

Ejemplares similares