Substrates of the Human Brain Proton-Organic Cation Antiporter and Comparison with Organic Cation Transporter 1 Activities

Many organic cations (OCs) may be transported through membranes by a genetically still uncharacterized proton-organic cation (H + OC) antiporter. Here, we characterized an extended substrate spectrum of this antiporter. We studied the uptake of 72 drugs in hCMEC/D3 cells as a model of the human bloo...

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Detalles Bibliográficos
Autores principales: Doetsch, David A., Ansari, Salim, Jensen, Ole, Gebauer, Lukas, Dücker, Christof, Brockmöller, Jürgen, Sachkova, Alexandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369162/
https://www.ncbi.nlm.nih.gov/pubmed/35955563
http://dx.doi.org/10.3390/ijms23158430

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369162/
https://www.ncbi.nlm.nih.gov/pubmed/35955563
http://dx.doi.org/10.3390/ijms23158430

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