Vitamin D Analogs Bearing C-20 Modifications Stabilize the Agonistic Conformation of Non-Responsive Vitamin D Receptor Variants

The Vitamin D receptor (VDR) plays a key role in calcium homeostasis, as well as in cell proliferation and differentiation. Among the large number of VDR ligands that have been developed, we have previously shown that BXL-62 and Gemini-72, two C-20-modified vitamin D analogs are highly potent VDR ag...

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Detalles Bibliográficos
Autores principales: Belorusova, Anna Y., Rovito, Daniela, Chebaro, Yassmine, Doms, Stefanie, Verlinden, Lieve, Verstuyf, Annemieke, Metzger, Daniel, Rochel, Natacha, Laverny, Gilles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369186/
https://www.ncbi.nlm.nih.gov/pubmed/35955580
http://dx.doi.org/10.3390/ijms23158445

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369186/
https://www.ncbi.nlm.nih.gov/pubmed/35955580
http://dx.doi.org/10.3390/ijms23158445

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