Thiosemicarbazones Can Act Synergistically with Anthracyclines to Downregulate CHEK1 Expression and Induce DNA Damage in Cell Lines Derived from Pediatric Solid Tumors

Anticancer therapy by anthracyclines often leads to the development of multidrug resistance (MDR), with subsequent treatment failure. Thiosemicarbazones have been previously suggested as suitable anthracycline partners due to their ability to overcome drug resistance through dual Pgp-dependent cytot...

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Detalles Bibliográficos
Autores principales: Paukovcekova, Silvia, Krchniakova, Maria, Chlapek, Petr, Neradil, Jakub, Skoda, Jan, Veselska, Renata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369312/
https://www.ncbi.nlm.nih.gov/pubmed/35955683
http://dx.doi.org/10.3390/ijms23158549

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369312/
https://www.ncbi.nlm.nih.gov/pubmed/35955683
http://dx.doi.org/10.3390/ijms23158549

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