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Thiosemicarbazones Can Act Synergistically with Anthracyclines to Downregulate CHEK1 Expression and Induce DNA Damage in Cell Lines Derived from Pediatric Solid Tumors
Anticancer therapy by anthracyclines often leads to the development of multidrug resistance (MDR), with subsequent treatment failure. Thiosemicarbazones have been previously suggested as suitable anthracycline partners due to their ability to overcome drug resistance through dual Pgp-dependent cytot...
Autores principales: | Paukovcekova, Silvia, Krchniakova, Maria, Chlapek, Petr, Neradil, Jakub, Skoda, Jan, Veselska, Renata |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369312/ https://www.ncbi.nlm.nih.gov/pubmed/35955683 http://dx.doi.org/10.3390/ijms23158549 |
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