Ligand and Structure-Based Virtual Screening in Combination, to Evaluate Small Organic Molecules as Inhibitors for the XIAP Anti-Apoptotic Protein: The Xanthohumol Hypothesis

Herein, we propose two chalcone molecules, (E)-1-(4-methoxyphenyl)-3-(p-tolyl) prop-2-en-1-one and (E)-3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl) prop-2-en-1-one, based on the anticancer bioactive molecule Xanthohumol, which are suitable for further in vitro and in vivo studies. Their ability to...

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Detalles Bibliográficos
Autores principales: Mavra, Angeliki, Petrou, Christos C., Vlasiou, Manos C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369490/
https://www.ncbi.nlm.nih.gov/pubmed/35956774
http://dx.doi.org/10.3390/molecules27154825

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369490/
https://www.ncbi.nlm.nih.gov/pubmed/35956774
http://dx.doi.org/10.3390/molecules27154825

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