Actions of Novel Angiotensin Receptor Blocking Drugs, Bisartans, Relevant for COVID-19 Therapy: Biased Agonism at Angiotensin Receptors and the Beneficial Effects of Neprilysin in the Renin Angiotensin System

Angiotensin receptor blockers (ARBs) used in the treatment of hypertension and potentially in SARS-CoV-2 infection exhibit inverse agonist effects at angiotensin AR1 receptors, suggesting the receptor may have evolved to accommodate naturally occurring angiotensin ‘antipeptides’. Screening of the hu...

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Detalles Bibliográficos
Autores principales: Moore, Graham J., Ridgway, Harry, Kelaidonis, Konstantinos, Chasapis, Christos T., Ligielli, Irene, Mavromoustakos, Thomas, Bojarska, Joanna, Matsoukas, John M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369639/
https://www.ncbi.nlm.nih.gov/pubmed/35956801
http://dx.doi.org/10.3390/molecules27154854

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369639/
https://www.ncbi.nlm.nih.gov/pubmed/35956801
http://dx.doi.org/10.3390/molecules27154854

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