Discovery of New Inhibitors of eEF2K from Traditional Chinese Medicine Based on In Silico Screening and In Vitro Experimental Validation

Eukaryotic elongation factor 2 kinase (eEF2K) is a highly conserved α kinase and is increasingly considered as an attractive therapeutic target for cancer as well as other diseases. However, so far, no selective and potent inhibitors of eEF2K have been identified. In this study, pharmacophore screen...

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Detalles Bibliográficos
Autores principales: Fu, Qinghua, Liu, Xiaomei, Li, Yan, Wang, Peng, Wu, Tian, Xiao, Haihan, Zhao, Yameng, Liao, Qichao, Song, Ziyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369671/
https://www.ncbi.nlm.nih.gov/pubmed/35956836
http://dx.doi.org/10.3390/molecules27154886

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369671/
https://www.ncbi.nlm.nih.gov/pubmed/35956836
http://dx.doi.org/10.3390/molecules27154886

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