Exploring the Interaction of G-quadruplex Binders with a (3 + 1) Hybrid G-quadruplex Forming Sequence within the PARP1 Gene Promoter Region

The enzyme PARP1 is an attractive target for cancer therapy, as it is involved in DNA repair processes. Several PARP1 inhibitors have been approved for clinical treatments. However, the rapid outbreak of resistance is seriously threatening the efficacy of these compounds, and alternative strategies...

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Detalles Bibliográficos
Autores principales: Mazzini, Stefania, Princiotto, Salvatore, Artali, Roberto, Musso, Loana, Aviñó, Anna, Eritja, Ramon, Gargallo, Raimundo, Dallavalle, Sabrina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369712/
https://www.ncbi.nlm.nih.gov/pubmed/35897968
http://dx.doi.org/10.3390/molecules27154792

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369712/
https://www.ncbi.nlm.nih.gov/pubmed/35897968
http://dx.doi.org/10.3390/molecules27154792

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