Cargando…

Exploring the Interaction of G-quadruplex Binders with a (3 + 1) Hybrid G-quadruplex Forming Sequence within the PARP1 Gene Promoter Region

The enzyme PARP1 is an attractive target for cancer therapy, as it is involved in DNA repair processes. Several PARP1 inhibitors have been approved for clinical treatments. However, the rapid outbreak of resistance is seriously threatening the efficacy of these compounds, and alternative strategies...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mazzini, Stefania, Princiotto, Salvatore, Artali, Roberto, Musso, Loana, Aviñó, Anna, Eritja, Ramon, Gargallo, Raimundo, Dallavalle, Sabrina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369712/ https://www.ncbi.nlm.nih.gov/pubmed/35897968 http://dx.doi.org/10.3390/molecules27154792

Ejemplares similares

Investigation of the Complexes Formed between PARP1 Inhibitors and PARP1 G-Quadruplex at the Gene Promoter Region
por: Dallavalle, Sabrina, et al.
Publicado: (2021)

G-quadruplex binding properties of a potent PARP-1 inhibitor derived from 7-azaindole-1-carboxamide
por: Dallavalle, Sabrina, et al.
Publicado: (2021)

Exploring the Interaction of Curaxin CBL0137 with G-Quadruplex DNA Oligomers
por: Dallavalle, Sabrina, et al.
Publicado: (2021)

Investigation of the Interaction between Aloe vera Anthraquinone Metabolites and c-Myc and C-Kit G-Quadruplex DNA Structures
por: Dallavalle, Sabrina, et al.
Publicado: (2022)

Stabilization of c-KIT G-Quadruplex DNA Structures by the RNA Polymerase I Inhibitors BMH-21 and BA-41
por: Mazzini, Stefania, et al.
Publicado: (2019)

Structure and Stability of Human Telomeric G-Quadruplex with Preclinical 9-Amino Acridines
por: Ferreira, Ruben, et al.
Publicado: (2013)

Synthesis and Investigation of the G-Quadruplex Binding Properties of Kynurenic Acid Derivatives with a Dihydroimidazoquinoline-3,5-dione Core
por: Mazzini, Stefania, et al.
Publicado: (2022)

Correction: Structure and Stability of Human Telomeric G-Quadruplex with Preclinical 9-Amino Acridines
por: Ferreira, Ruben, et al.
Publicado: (2013)

A pH-dependent bolt involving cytosine bases located in the lateral loops of antiparallel G-quadruplex structures within the SMARCA4 gene promotor
por: Benabou, Sanae, et al.
Publicado: (2019)

Exploring the Interaction of New Pyridoquinazoline Derivatives with G-Quadruplex in the c-MYC Promoter Region
por: Princiotto, Salvatore, et al.
Publicado: (2023)

Synthesis and G-Quadruplex-Binding Properties of Defined Acridine Oligomers
por: Ferreira, Rubén, et al.
Publicado: (2010)

Variable-Temperature Size Exclusion Chromatography for the Study of the Structural Changes in G-Quadruplex
por: Benabou, Sanae, et al.
Publicado: (2013)

Properties of Parallel Tetramolecular G-Quadruplex Carrying N-Acetylgalactosamine as Potential Enhancer for Oligonucleotide Delivery to Hepatocytes
por: Clua, Anna, et al.
Publicado: (2022)

Tuning G-Quadruplex Nanostructures with Lipids. Towards Designing Hybrid Scaffolds for Oligonucleotide Delivery †
por: Grijalvo, Santiago, et al.
Publicado: (2020)

Resolution of a structural competition involving dimeric G-quadruplex and its C-rich complementary strand
por: Jaumot, Joaquim, et al.
Publicado: (2006)

G-quadruplex–R-loop interactions and the mechanism of anticancer G-quadruplex binders
por: Miglietta, Giulia, et al.
Publicado: (2020)

G-quadruplex–R-loop interactions and the mechanism of anticancer G-quadruplex binders
por: Miglietta, Giulia, et al.
Publicado: (2020)

Correction: Clua et al. Properties of Parallel Tetramolecular G-Quadruplex Carrying N-Acetylgalactosamine as Potential Enhancer for Oligonucleotide Delivery to Hepatocytes. Molecules 2022, 27, 3944
por: Clua, Anna, et al.
Publicado: (2022)

Putative SARS-CoV-2 M(pro) Inhibitors from an In-House Library of Natural and Nature-Inspired Products: A Virtual Screening and Molecular Docking Study
por: Mazzini, Stefania, et al.
Publicado: (2020)

G-Quadruplex Nucleic Acids
por: Eritja, Ramon, et al.
Publicado: (2010)

Correction to article ‘G-quadruplex–R-loop interactions and the mechanism of anticancer G-quadruplex binders’
por: Miglietta, Giulia, et al.
Publicado: (2021)

New Antimicrobials Based on the Adarotene Scaffold with Activity against Multi-Drug Resistant Staphylococcus aureus and Vancomycin-Resistant Enterococcus
por: Princiotto, Salvatore, et al.
Publicado: (2021)

G-Quadruplex loops regulate PARP-1 enzymatic activation
por: Edwards, Andrea D, et al.
Publicado: (2020)

Metal-Based G-Quadruplex Binders for Cancer Theranostics
por: Palma, Elisa, et al.
Publicado: (2021)

The Effect of Small Cosolutes that Mimic Molecular Crowding Conditions on the Stability of Triplexes Involving Duplex DNA
por: Aviñó, Anna, et al.
Publicado: (2016)

Synthesis and Structural Characterization of Stable Branched DNA G-Quadruplexes Using the Trebler Phosphoramidite
por: Ferreira, Rubén, et al.
Publicado: (2012)

The human mitochondrial transcription factor A is a versatile G-quadruplex binding protein
por: Lyonnais, Sébastien, et al.
Publicado: (2017)

Dinickel–Salphen Complexes as Binders of Human Telomeric Dimeric G‐Quadruplexes
por: Zhou, Chun‐Qiong, et al.
Publicado: (2017)

Structure of a (3+1) hybrid G-quadruplex in the PARP1 promoter
por: Sengar, Anjali, et al.
Publicado: (2019)

Electrochemical and AFM Characterization of G-Quadruplex Electrochemical Biosensors and Applications
por: Chiorcea-Paquim, Ana-Maria, et al.
Publicado: (2018)

Corrigendum: The human mitochondrial transcription factor A is a versatile G-quadruplex binding protein
por: Lyonnais, Sébastien, et al.
Publicado: (2017)

Detection of CpG Methylation in G-Quadruplex Forming Sequences Using G-Quadruplex Ligands
por: Hasegawa, Hijiri, et al.
Publicado: (2021)

Structural Properties of G,T-Parallel Duplexes
por: Aviñó, Anna, et al.
Publicado: (2010)

G-quadruplexes and G-quadruplex ligands: targets and tools in antiviral therapy
por: Ruggiero, Emanuela, et al.
Publicado: (2018)

A Water‐Soluble Tetraazaperopyrene Dye as Strong G‐Quadruplex DNA Binder
por: Hahn, Lena, et al.
Publicado: (2016)

G-quadruplex binders as cytostatic modulators of innate immune genes in cancer cells
por: Miglietta, Giulia, et al.
Publicado: (2021)

Chromene Derivatives as Selective TERRA G-Quadruplex RNA Binders with Antiproliferative Properties
por: Rocca, Roberta, et al.
Publicado: (2022)

Development and application of metallo-phthalocyanines as potent G-quadruplex DNA binders and photosensitizers
por: Gil-Martínez, Ariadna, et al.
Publicado: (2023)

G-quadruplexes and helicases
por: Mendoza, Oscar, et al.
Publicado: (2016)

G-Quadruplexes (GQU)
por: Haider, Shozeb, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_rvnp1cept3u8etmmn17fh9lp4b