UHPLC Enantiomer Resolution for the ɑ/β-Adrenoceptor Antagonist R/S-Carvedilol and Its Major Active Metabolites on Chiralpak IB N-5

Carvedilol (CAR), a racemic lipophilic aryloxy propanolamine, acts as a selective α(1)-adrenoreceptor antagonist and a nonselective β-adrenoreceptor antagonist. CAR metabolism mainly produces three active metabolites: desmethyl carvedilol (DMC), 4′-hydroxy carvedilol (4′OHC) and 5′-hydroxy carvedilo...

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Detalles Bibliográficos
Autores principales: Samir, Liza, Hanafi, Rasha, El Deeb, Sami, Spahn-Langguth, Hilde
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9370150/
https://www.ncbi.nlm.nih.gov/pubmed/35956942
http://dx.doi.org/10.3390/molecules27154998

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9370150/
https://www.ncbi.nlm.nih.gov/pubmed/35956942
http://dx.doi.org/10.3390/molecules27154998

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