Identification of Novel 4′-O-Demethyl-epipodophyllotoxin Derivatives as Antitumor Agents Targeting Topoisomerase II

C4 variation of 4′-O-demethyl-epipodophyllotoxin (DMEP) is an effective approach to optimize the antitumor spectra of this compound class. Accordingly, two series of novel DMEP derivatives were synthesized, and as expected, the antitumor spectra of these derivatives varied with different C4 substitu...

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Detalles Bibliográficos
Autores principales: Xi, Wenli, Sun, Hua, Bastow, Kenneth F., Xiao, Zhiyan, Lee, Kuo-Hsiung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9370175/
https://www.ncbi.nlm.nih.gov/pubmed/35956979
http://dx.doi.org/10.3390/molecules27155029

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9370175/
https://www.ncbi.nlm.nih.gov/pubmed/35956979
http://dx.doi.org/10.3390/molecules27155029

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