New Quinoxaline-Based Derivatives as PARP-1 Inhibitors: Design, Synthesis, Antiproliferative, and Computational Studies

Herein, 2,3-dioxo-1,2,3,4-tetrahydroquinoxaline was used as a bio-isosteric scaffold to the phthalazinone motif of the standard drug Olaparib to design and synthesize new derivatives of potential PARP-1 inhibitory activity using the 6-sulfonohydrazide analog 3 as the key intermediate. Although the n...

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Detalles Bibliográficos
Autores principales: Syam, Yasmin M., Anwar, Manal M., Abd El-Karim, Somaia S., Elokely, Khaled M., Abdelwahed, Sameh H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9370283/
https://www.ncbi.nlm.nih.gov/pubmed/35956876
http://dx.doi.org/10.3390/molecules27154924

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9370283/
https://www.ncbi.nlm.nih.gov/pubmed/35956876
http://dx.doi.org/10.3390/molecules27154924

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