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Lower Non-Heme Iron Absorption in Healthy Females from Single Meals with Texturized Fava Bean Protein Compared to Beef and Cod Protein Meals: Two Single-Blinded Randomized Trials

Meat analogs based on plant protein extracts are rising in popularity as meat consumption declines. A dietary shift away from meat, which has a high iron bioavailability, may have a negative effect on the amount of iron absorbed from the diet. Iron absorption from legumes cultivated in regions not s...

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Autores principales: Mayer Labba, Inger-Cecilia, Hoppe, Michael, Gramatkovski, Elisabeth, Hjellström, Martin, Abdollahi, Mehdi, Undeland, Ingrid, Hulthén, Lena, Sandberg, Ann-Sofie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9370477/
https://www.ncbi.nlm.nih.gov/pubmed/35956338
http://dx.doi.org/10.3390/nu14153162
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author Mayer Labba, Inger-Cecilia
Hoppe, Michael
Gramatkovski, Elisabeth
Hjellström, Martin
Abdollahi, Mehdi
Undeland, Ingrid
Hulthén, Lena
Sandberg, Ann-Sofie
author_facet Mayer Labba, Inger-Cecilia
Hoppe, Michael
Gramatkovski, Elisabeth
Hjellström, Martin
Abdollahi, Mehdi
Undeland, Ingrid
Hulthén, Lena
Sandberg, Ann-Sofie
author_sort Mayer Labba, Inger-Cecilia
collection PubMed
description Meat analogs based on plant protein extracts are rising in popularity as meat consumption declines. A dietary shift away from meat, which has a high iron bioavailability, may have a negative effect on the amount of iron absorbed from the diet. Iron absorption from legumes cultivated in regions not suitable for soy production, such as fava bean, has not yet been explored. The aim of this study was to evaluate non-heme iron absorption from a meal with texturized fava bean protein compared to beef and cod protein meals. The study included two single-blinded iron isotope trials in healthy Swedish women of the ages 18–45 years, each of whom served as their own control. The participants were served matched test meals containing beef and fava bean protein (Study 1) or cod and fava bean protein (Study 2) with radiolabeled non-heme iron (55)Fe and (59)Fe. The absorption of non-heme iron from test meals was measured by whole-body counting and erythrocyte incorporation. The absorption of non-heme iron, measured as erythrocyte incorporation ratio, from beef protein meal was 4.2 times higher compared to texturized fava bean meal, and absorption from cod protein meal was 2.7 times higher compared to the fava bean meal. The adjusted non-heme iron absorption, normalized to a 40% reference dose uptake, was 9.2% for cod protein meal, 21.7% for beef protein meal, and 4.2% for texturized fava bean meal. A fava bean protein meal has markedly lower iron bioavailability in healthy females compared with a meal of beef or cod protein. Therefore, a dietary shift from meat and fish protein to fava bean protein may increase the risk of iron deficiency.
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spelling pubmed-93704772022-08-12 Lower Non-Heme Iron Absorption in Healthy Females from Single Meals with Texturized Fava Bean Protein Compared to Beef and Cod Protein Meals: Two Single-Blinded Randomized Trials Mayer Labba, Inger-Cecilia Hoppe, Michael Gramatkovski, Elisabeth Hjellström, Martin Abdollahi, Mehdi Undeland, Ingrid Hulthén, Lena Sandberg, Ann-Sofie Nutrients Article Meat analogs based on plant protein extracts are rising in popularity as meat consumption declines. A dietary shift away from meat, which has a high iron bioavailability, may have a negative effect on the amount of iron absorbed from the diet. Iron absorption from legumes cultivated in regions not suitable for soy production, such as fava bean, has not yet been explored. The aim of this study was to evaluate non-heme iron absorption from a meal with texturized fava bean protein compared to beef and cod protein meals. The study included two single-blinded iron isotope trials in healthy Swedish women of the ages 18–45 years, each of whom served as their own control. The participants were served matched test meals containing beef and fava bean protein (Study 1) or cod and fava bean protein (Study 2) with radiolabeled non-heme iron (55)Fe and (59)Fe. The absorption of non-heme iron from test meals was measured by whole-body counting and erythrocyte incorporation. The absorption of non-heme iron, measured as erythrocyte incorporation ratio, from beef protein meal was 4.2 times higher compared to texturized fava bean meal, and absorption from cod protein meal was 2.7 times higher compared to the fava bean meal. The adjusted non-heme iron absorption, normalized to a 40% reference dose uptake, was 9.2% for cod protein meal, 21.7% for beef protein meal, and 4.2% for texturized fava bean meal. A fava bean protein meal has markedly lower iron bioavailability in healthy females compared with a meal of beef or cod protein. Therefore, a dietary shift from meat and fish protein to fava bean protein may increase the risk of iron deficiency. MDPI 2022-07-30 /pmc/articles/PMC9370477/ /pubmed/35956338 http://dx.doi.org/10.3390/nu14153162 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mayer Labba, Inger-Cecilia
Hoppe, Michael
Gramatkovski, Elisabeth
Hjellström, Martin
Abdollahi, Mehdi
Undeland, Ingrid
Hulthén, Lena
Sandberg, Ann-Sofie
Lower Non-Heme Iron Absorption in Healthy Females from Single Meals with Texturized Fava Bean Protein Compared to Beef and Cod Protein Meals: Two Single-Blinded Randomized Trials
title Lower Non-Heme Iron Absorption in Healthy Females from Single Meals with Texturized Fava Bean Protein Compared to Beef and Cod Protein Meals: Two Single-Blinded Randomized Trials
title_full Lower Non-Heme Iron Absorption in Healthy Females from Single Meals with Texturized Fava Bean Protein Compared to Beef and Cod Protein Meals: Two Single-Blinded Randomized Trials
title_fullStr Lower Non-Heme Iron Absorption in Healthy Females from Single Meals with Texturized Fava Bean Protein Compared to Beef and Cod Protein Meals: Two Single-Blinded Randomized Trials
title_full_unstemmed Lower Non-Heme Iron Absorption in Healthy Females from Single Meals with Texturized Fava Bean Protein Compared to Beef and Cod Protein Meals: Two Single-Blinded Randomized Trials
title_short Lower Non-Heme Iron Absorption in Healthy Females from Single Meals with Texturized Fava Bean Protein Compared to Beef and Cod Protein Meals: Two Single-Blinded Randomized Trials
title_sort lower non-heme iron absorption in healthy females from single meals with texturized fava bean protein compared to beef and cod protein meals: two single-blinded randomized trials
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9370477/
https://www.ncbi.nlm.nih.gov/pubmed/35956338
http://dx.doi.org/10.3390/nu14153162
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