A Small Natural Molecule S3 Protects Retinal Ganglion Cells and Promotes Parkin-Mediated Mitophagy against Excitotoxicity

Glutamate excitotoxicity may contribute to retinal ganglion cell (RGC) degeneration in glaucoma and other optic neuropathies, leading to irreversible blindness. Growing evidence has linked impaired mitochondrial quality control with RGCs degeneration, while parkin, an E3 ubiquitin ligase, has proved...

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Detalles Bibliográficos
Autores principales: Zhuang, Dongli, Zhang, Rong, Liu, Haiyang, Dai, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9370668/
https://www.ncbi.nlm.nih.gov/pubmed/35956907
http://dx.doi.org/10.3390/molecules27154957

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9370668/
https://www.ncbi.nlm.nih.gov/pubmed/35956907
http://dx.doi.org/10.3390/molecules27154957

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