Network diffusion model predicts neurodegeneration in limb-onset Amyotrophic Lateral Sclerosis

OBJECTIVE: Emerging evidences suggest that the trans-neural propagation of phosphorylated 43-kDa transactive response DNA-binding protein (pTDP-43) contributes to neurodegeneration in Amyotrophic Lateral Sclerosis (ALS). We investigated whether Network Diffusion Model (NDM), a biophysical model of s...

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Detalles Bibliográficos
Autores principales: Bhattarai, Anjan, Chen, Zhaolin, Chua, Phyllis, Talman, Paul, Mathers, Susan, Chapman, Caron, Howe, James, Lee, C. M. Sarah, Lie, Yenni, Poudel, Govinda R., Egan, Gary F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371353/
https://www.ncbi.nlm.nih.gov/pubmed/35951510
http://dx.doi.org/10.1371/journal.pone.0272736

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371353/
https://www.ncbi.nlm.nih.gov/pubmed/35951510
http://dx.doi.org/10.1371/journal.pone.0272736

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