The Rab GTPase activating protein TBC-2 regulates endosomal localization of DAF-16 FOXO and lifespan

FOXO transcription factors have been shown to regulate longevity in model organisms and are associated with longevity in humans. To gain insight into how FOXO functions to increase lifespan, we examined the subcellular localization of DAF-16 in C. elegans. We show that DAF-16 is localized to endosom...

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Detalles Bibliográficos
Autores principales: Meraş, İçten, Chotard, Laëtitia, Liontis, Thomas, Ratemi, Zakaria, Wiles, Benjamin, Seo, Jung Hwa, Van Raamsdonk, Jeremy M., Rocheleau, Christian E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371356/
https://www.ncbi.nlm.nih.gov/pubmed/35913999
http://dx.doi.org/10.1371/journal.pgen.1010328

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371356/
https://www.ncbi.nlm.nih.gov/pubmed/35913999
http://dx.doi.org/10.1371/journal.pgen.1010328

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