Tcf-1 promotes genomic instability and T cell transformation in response to aberrant β-catenin activation

Understanding the mechanisms promoting chromosomal translocations of the rearranging receptor loci in leukemia and lymphoma remains incomplete. Here we show that leukemias induced by aberrant activation of β-catenin in thymocytes, which bear recurrent Tcra/Myc-Pvt1 translocations, depend on Tcf-1. T...

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Detalles Bibliográficos
Autores principales: Arnovitz, Stephen, Mathur, Priya, Tracy, Melissa, Mohsin, Azam, Mondal, Soumi, Quandt, Jasmin, Hernandez, Kyle M., Khazaie, Khashayarsha, Dose, Marei, Emmanuel, Akinola Olumide, Gounari, Fotini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371646/
https://www.ncbi.nlm.nih.gov/pubmed/35921443
http://dx.doi.org/10.1073/pnas.2201493119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371646/
https://www.ncbi.nlm.nih.gov/pubmed/35921443
http://dx.doi.org/10.1073/pnas.2201493119

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