CFI-402257, a TTK inhibitor, effectively suppresses hepatocellular carcinoma

Deregulation of cell cycle is a typical feature of cancer cells. Normal cells rely on the strictly coordinated spindle assembly checkpoint (SAC) to maintain the genome integrity and survive. However, cancer cells could bypass this checkpoint mechanism. In this study, we showed the clinical relevance...

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Detalles Bibliográficos
Autores principales: Chan, Cerise Yuen-Ki, Chiu, David Kung-Chun, Yuen, Vincent Wai-Hin, Law, Cheuk-Ting, Wong, Bowie Po-Yee, Thu, Kelsie Lynn, Cescon, David Ward, Soria-Bretones, Isabel, Cheu, Jacinth Wing-Sum, Lee, Derek, Tse, Aki Pui-Wah, Zhang, Misty Shuo, Tan, Kel Vin, Ng, Irene Oi-Lin, Khong, Pek-Lan, Yau, Thomas Chung-Cheung, Bray, Mark Robert, Mak, Tak Wah, Wong, Carmen Chak-Lui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371652/
https://www.ncbi.nlm.nih.gov/pubmed/35914158
http://dx.doi.org/10.1073/pnas.2119514119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371652/
https://www.ncbi.nlm.nih.gov/pubmed/35914158
http://dx.doi.org/10.1073/pnas.2119514119

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