Cargando…
A unified strategy for the total syntheses of eribulin and a macrolactam analogue of halichondrin B
A unified synthetic route for the total syntheses of eribulin and a macrolactam analog of halichondrin B is described. The key to the success of the current synthetic approach includes the employment of our reverse approach for the construction of cyclic ether structural motifs and a modified intram...
| Autores principales: | , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2022
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371655/ https://www.ncbi.nlm.nih.gov/pubmed/35930662 http://dx.doi.org/10.1073/pnas.2208938119 |