De novo mutations in KIF1A-associated neuronal disorder (KAND) dominant-negatively inhibit motor activity and axonal transport of synaptic vesicle precursors

KIF1A is a kinesin superfamily motor protein that transports synaptic vesicle precursors in axons. Cargo binding stimulates the dimerization of KIF1A molecules to induce processive movement along microtubules. Mutations in human Kif1a lead to a group of neurodegenerative diseases called KIF1A-associ...

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Detalles Bibliográficos
Autores principales: Anazawa, Yuzu, Kita, Tomoki, Iguchi, Rei, Hayashi, Kumiko, Niwa, Shinsuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371658/
https://www.ncbi.nlm.nih.gov/pubmed/35917346
http://dx.doi.org/10.1073/pnas.2113795119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371658/
https://www.ncbi.nlm.nih.gov/pubmed/35917346
http://dx.doi.org/10.1073/pnas.2113795119

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