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A theory of resistance to multiplexed gene drive demonstrates the significant role of weakly deleterious natural genetic variation
Evolution of resistance is a major barrier to successful deployment of gene-drive systems to suppress natural populations, which could greatly reduce the burden of many vector-borne diseases. Multiplexed guide RNAs (gRNAs) that require resistance mutations in all target cut sites are a promising ant...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371675/ https://www.ncbi.nlm.nih.gov/pubmed/35914131 http://dx.doi.org/10.1073/pnas.2200567119 |