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Inhibition of the angiotensin II type 2 receptor AT(2)R is a novel therapeutic strategy for glioblastoma
Glioblastoma (GBM) is an aggressive malignant primary brain tumor with limited therapeutic options. We show that the angiotensin II (AngII) type 2 receptor (AT(2)R) is a therapeutic target for GBM and that AngII, endogenously produced in GBM cells, promotes proliferation through AT(2)R. We repurpose...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371711/ https://www.ncbi.nlm.nih.gov/pubmed/35917342 http://dx.doi.org/10.1073/pnas.2116289119 |