Inhibition of the angiotensin II type 2 receptor AT(2)R is a novel therapeutic strategy for glioblastoma

Glioblastoma (GBM) is an aggressive malignant primary brain tumor with limited therapeutic options. We show that the angiotensin II (AngII) type 2 receptor (AT(2)R) is a therapeutic target for GBM and that AngII, endogenously produced in GBM cells, promotes proliferation through AT(2)R. We repurpose...

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Detalles Bibliográficos
Autores principales: Perryman, Richard, Renziehausen, Alexander, Shaye, Hamidreza, Kostagianni, Androniki D., Tsiailanis, Antonis D., Thorne, Thomas, Chatziathanasiadou, Maria V., Sivolapenko, Gregory B., El Mubarak, Mohamed Ahmed, Han, Gye Won, Zarzycka, Barbara, Katritch, Vsevolod, Lebon, Guillaume, Lo Nigro, Cristiana, Lattanzio, Laura, Morse, Sophie V., Choi, James J., O’Neill, Kevin, Kanaki, Zoi, Klinakis, Apostolos, Crook, Tim, Cherezov, Vadim, Tzakos, Andreas G., Syed, Nelofer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371711/
https://www.ncbi.nlm.nih.gov/pubmed/35917342
http://dx.doi.org/10.1073/pnas.2116289119

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