Loss of Ca(V)1.3 RNA editing enhances mouse hippocampal plasticity, learning, and memory

L-type Ca(V)1.3 calcium channels are expressed on the dendrites and soma of neurons, and there is a paucity of information about its role in hippocampal plasticity. Here, by genetic targeting to ablate Ca(V)1.3 RNA editing, we demonstrate that unedited Ca(V)1.3(ΔECS) mice exhibited improved learning...

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Detalles Bibliográficos
Autores principales: Zhai, Jing, Navakkode, Sheeja, Yeow, Sean Qing Zhang, Krishna-K, Kumar, Liang, Mui Cheng, Koh, Joanne Huifen, Wong, Rui Xiong, Yu, Wei Ping, Sajikumar, Sreedharan, Huang, Hua, Soong, Tuck Wah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371748/
https://www.ncbi.nlm.nih.gov/pubmed/35914168
http://dx.doi.org/10.1073/pnas.2203883119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371748/
https://www.ncbi.nlm.nih.gov/pubmed/35914168
http://dx.doi.org/10.1073/pnas.2203883119

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