Cargando…

Loss of Ca(V)1.3 RNA editing enhances mouse hippocampal plasticity, learning, and memory

L-type Ca(V)1.3 calcium channels are expressed on the dendrites and soma of neurons, and there is a paucity of information about its role in hippocampal plasticity. Here, by genetic targeting to ablate Ca(V)1.3 RNA editing, we demonstrate that unedited Ca(V)1.3(ΔECS) mice exhibited improved learning...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhai, Jing, Navakkode, Sheeja, Yeow, Sean Qing Zhang, Krishna-K, Kumar, Liang, Mui Cheng, Koh, Joanne Huifen, Wong, Rui Xiong, Yu, Wei Ping, Sajikumar, Sreedharan, Huang, Hua, Soong, Tuck Wah
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371748/ https://www.ncbi.nlm.nih.gov/pubmed/35914168 http://dx.doi.org/10.1073/pnas.2203883119

Ejemplares similares

Bidirectional modulation of hippocampal synaptic plasticity by Dopaminergic D4-receptors in the CA1 area of hippocampus
por: Navakkode, Sheeja, et al.
Publicado: (2017)

Deregulated expression of a longevity gene, Klotho, in the C9orf72 deletion mice with impaired synaptic plasticity and adult hippocampal neurogenesis
por: Ho, Wan Yun, et al.
Publicado: (2020)

Enhanced long-term potentiation and impaired learning in mice lacking alternative exon 33 of Ca(V)1.2 calcium channel
por: Navakkode, Sheeja, et al.
Publicado: (2022)

Sex matters in Alzheimer’s disease?
por: Navakkode, Sheeja, et al.
Publicado: (2022)

Epigenetic regulation of microglial phosphatidylinositol 3‐kinase pathway involved in long‐term potentiation and synaptic plasticity in rats
por: Saw, Genevieve, et al.
Publicado: (2019)

Tissue-selective restriction of RNA editing of Ca(V)1.3 by splicing factor SRSF9
por: Huang, Hua, et al.
Publicado: (2018)

Sex‐specific accelerated decay in time/activity‐dependent plasticity and associative memory in an animal model of Alzheimer's disease
por: Navakkode, Sheeja, et al.
Publicado: (2021)

Glucose derived carbon nanosphere (CSP) conjugated TTK21, an activator of the histone acetyltransferases CBP/p300, ameliorates amyloid‐beta 1–42 induced deficits in plasticity and associativity in hippocampal CA1 pyramidal neurons
por: Singh, Akash K., et al.
Publicado: (2022)

ApoE4 expression accelerates hippocampus-dependent cognitive deficits by enhancing Aβ impairment of insulin signaling in an Alzheimer’s disease mouse model
por: Chan, Elizabeth S., et al.
Publicado: (2016)

Alternative Splicing of L-type Ca(V)1.2 Calcium Channels: Implications in Cardiovascular Diseases
por: Hu, Zhenyu, et al.
Publicado: (2017)

Chelation of hippocampal zinc enhances long‐term potentiation and synaptic tagging/capture in CA1 pyramidal neurons of aged rats: implications to aging and memory
por: Shetty, Mahesh Shivarama, et al.
Publicado: (2016)

Epigenetic regulation by G9a/GLP complex ameliorates amyloid‐beta 1‐42 induced deficits in long‐term plasticity and synaptic tagging/capture in hippocampal pyramidal neurons
por: Sharma, Mahima, et al.
Publicado: (2017)

Dopamine D1/D5 receptor signaling regulates synaptic cooperation and competition in hippocampal CA1 pyramidal neurons via sustained ERK1/2 activation
por: Shivarama Shetty, Mahesh, et al.
Publicado: (2016)

Modest Ca(V)1.3(42)-selective inhibition by compound 8 is β-subunit dependent
por: Huang, Hua, et al.
Publicado: (2014)

Group III metabotropic glutamate receptors gate long-term potentiation and synaptic tagging/capture in rat hippocampal area CA2
por: Dasgupta, Ananya, et al.
Publicado: (2020)

Age‐related changes in hippocampal‐dependent synaptic plasticity and memory mediated by p75 neurotrophin receptor
por: Wong, Lik‐Wei, et al.
Publicado: (2021)

Inhibition of lysine methyltransferase G9a/GLP reinstates long-term synaptic plasticity and synaptic tagging/capture by facilitating protein synthesis in the hippocampal CA1 area of APP/PS1 mouse model of Alzheimer’s disease
por: Han, Javan Lee Tze, et al.
Publicado: (2021)

Understanding alternative splicing of Ca(v)1.2 calcium channels for a new approach towards individualized medicine
por: Liao, Ping, et al.
Publicado: (2010)

Nitric Oxide, Iron and Neurodegeneration
por: Liu, Chao, et al.
Publicado: (2019)

Tumor-mediated microbiota alteration impairs synaptic tagging/capture in the hippocampal CA1 area via IL-1β production
por: Zhu, Ying, et al.
Publicado: (2023)

Dynamic regulation of RNA editing of ion channels and receptors in the mammalian nervous system
por: Tan, Bao Zhen, et al.
Publicado: (2009)

MicroRNA‐134‐5p inhibition rescues long‐term plasticity and synaptic tagging/capture in an Aβ(1–42)‐induced model of Alzheimer’s disease
por: Baby, Nimmi, et al.
Publicado: (2019)

Investigation of Synaptic Tagging/Capture and Cross-capture using Acute Hippocampal Slices from Rodents
por: Shetty, Mahesh Shivarama, et al.
Publicado: (2015)

Characterization of Ca(V)1.2 exon 33 heterozygous knockout mice and negative correlation between Rbfox1 and Ca(V)1.2 exon 33 expressions in human heart failure
por: Wang, Juejin, et al.
Publicado: (2017)

Hydroxychloroquine lowers Alzheimer’s disease and related dementias risk and rescues molecular phenotypes related to Alzheimer’s disease
por: Varma, Vijay R., et al.
Publicado: (2022)

Epigenetics: the panacea for cognitive decline?
por: Sharma, Mahima, et al.
Publicado: (2018)

Interaction of inhibition and synaptic plasticity in a model of the hippocampal CA1 microcircuit
por: Saudargienė, Aušra, et al.
Publicado: (2011)

A critical period for learning and plastic changes at hippocampal CA1 synapses
por: Sakimoto, Yuya, et al.
Publicado: (2022)

Inhibitory Metaplasticity in Juvenile Stressed Rats Restores Associative Memory in Adulthood by Regulating Epigenetic Complex G9a/GLP
por: Raghuraman, Radha, et al.
Publicado: (2022)

Dopamine D(2)R is Required for Hippocampal-dependent Memory and Plasticity at the CA3-CA1 Synapse
por: Espadas, Isabel, et al.
Publicado: (2020)

A critical role for CaMKII in behavioral timescale synaptic plasticity in hippocampal CA1 pyramidal neurons
por: Xiao, Kuo, et al.
Publicado: (2023)

Histone deacetylase 3 inhibition re-establishes synaptic tagging and capture in aging through the activation of nuclear factor kappa B
por: Sharma, Mahima, et al.
Publicado: (2015)

Endocannabinoids Differentially Modulate Synaptic Plasticity in Rat Hippocampal CA1 Pyramidal Neurons
por: Xu, Jian-Yi, et al.
Publicado: (2010)

Effect of acute fentanyl treatment on synaptic plasticity in the hippocampal CA1 region in rats
por: Tian, Hai, et al.
Publicado: (2015)

RGS14 Restricts Plasticity in Hippocampal CA2 by Limiting Postsynaptic Calcium Signaling
por: Evans, Paul R., et al.
Publicado: (2018)

Coexistence of Multiple Types of Synaptic Plasticity in Individual Hippocampal CA1 Pyramidal Neurons
por: Edelmann, Elke, et al.
Publicado: (2017)

Long-term plasticity in identified hippocampal GABAergic interneurons in the CA1 area in vivo
por: Lau, Petrina Yau-Pok, et al.
Publicado: (2016)

Circadian Modulation of Neurons and Astrocytes Controls Synaptic Plasticity in Hippocampal Area CA1
por: McCauley, John P., et al.
Publicado: (2020)

Aberrant Splicing Promotes Proteasomal Degradation of L-type Ca(V)1.2 Calcium Channels by Competitive Binding for Ca(V)β Subunits in Cardiac Hypertrophy
por: Hu, Zhenyu, et al.
Publicado: (2016)

Computer Modeling of Alzheimer’s Disease—Simulations of Synaptic Plasticity and Memory in the CA3-CA1 Hippocampal Formation Microcircuit
por: Świetlik, Dariusz, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_002o1b5hffaehsq4mulbh796l4