An integrated metabolomic and proteomic approach for the identification of covalent inhibitors of the main protease (M(pro)) of SARS-COV-2 from crude natural extracts

M(pro) represents one of the most promising drug targets for SARS-Cov-2, as it plays a crucial role in the maturation of viral polyproteins into functional proteins. HTS methods are currently used to screen M(pro) inhibitors, and rely on searching chemical databases and compound libraries, meaning t...

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Detalles Bibliográficos
Autores principales: Baron, Giovanna, Borella, Sofia, della Vedova, Larissa, Vittorio, Serena, Vistoli, Giulio, Carini, Marina, Aldini, Giancarlo, Altomare, Alessandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371774/
https://www.ncbi.nlm.nih.gov/pubmed/36027618
http://dx.doi.org/10.1016/j.talanta.2022.123824

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371774/
https://www.ncbi.nlm.nih.gov/pubmed/36027618
http://dx.doi.org/10.1016/j.talanta.2022.123824

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