Daurisoline Inhibits ESCC by Inducing G1 Cell Cycle Arrest and Activating ER Stress to Trigger Noxa-Dependent Intrinsic and CHOP-DR5-Dependent Extrinsic Apoptosis via p-eIF2α-ATF4 Axis

Esophageal squamous cell carcinoma (ESCC), one of the most malignant human cancers in clinic, requires novel treatment. Daurisoline (DAS) is a component of traditional Chinese herb, which exhibits anti-cancer effects by autophagy inhibition and metastasis suppression. However, the effect and mechani...

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Detalles Bibliográficos
Autores principales: Yuan, Shuying, Pan, Yongfu, Xu, Tong, Zhang, Li, Chen, Xihui, Wang, Fengying, Liu, Qian, Jia, Lijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371853/
https://www.ncbi.nlm.nih.gov/pubmed/35965681
http://dx.doi.org/10.1155/2022/5382263

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371853/
https://www.ncbi.nlm.nih.gov/pubmed/35965681
http://dx.doi.org/10.1155/2022/5382263

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