R-loop-induced irreparable DNA damage evades checkpoint detection in the C. elegans germline

Accumulation of DNA–RNA hybrids in the form of R-loops can result in replication–transcription conflict that leads to the formation of DNA double strand breaks (DSBs). Using null mutants for the two Caenorhabditis elegans genes encoding for RNaseH1 and RNaseH2, we identify novel effects of R-loop ac...

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Detalles Bibliográficos
Autores principales: Hicks, Tara, Koury, Emily, McCabe, Caleb, Williams, Cameron, Crahan, Caroline, Smolikove, Sarit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371901/
https://www.ncbi.nlm.nih.gov/pubmed/35871299
http://dx.doi.org/10.1093/nar/gkac621

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371901/
https://www.ncbi.nlm.nih.gov/pubmed/35871299
http://dx.doi.org/10.1093/nar/gkac621

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