In vitro reconstitution reveals a key role of human mitochondrial EXOG in RNA primer processing

The removal of RNA primers is essential for mitochondrial DNA (mtDNA) replication. Several nucleases have been implicated in RNA primer removal in human mitochondria, however, no conclusive mechanism has been elucidated. Here, we reconstituted minimal in vitro system capable of processing RNA primer...

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Detalles Bibliográficos
Autores principales: Karlowicz, Anna, Dubiel, Andrzej B, Czerwinska, Jolanta, Bledea, Adela, Purzycki, Piotr, Grzelewska, Marta, McAuley, Ryan J, Szczesny, Roman J, Brzuska, Gabriela, Krol, Ewelina, Szczesny, Bartosz, Szymanski, Michal R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371904/
https://www.ncbi.nlm.nih.gov/pubmed/35819194
http://dx.doi.org/10.1093/nar/gkac581

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371904/
https://www.ncbi.nlm.nih.gov/pubmed/35819194
http://dx.doi.org/10.1093/nar/gkac581

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