Systematic comparison of CRISPR-based transcriptional activators uncovers gene-regulatory features of enhancer–promoter interactions

Nuclease-inactivated CRISPR/Cas-based (dCas-based) systems have emerged as powerful technologies to synthetically reshape the human epigenome and gene expression. Despite the increasing adoption of these platforms, their relative potencies and mechanistic differences are incompletely characterized,...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Kaiyuan, Escobar, Mario, Li, Jing, Mahata, Barun, Goell, Jacob, Shah, Spencer, Cluck, Madeleine, Hilton, Isaac B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371918/
https://www.ncbi.nlm.nih.gov/pubmed/35849129
http://dx.doi.org/10.1093/nar/gkac582

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371918/
https://www.ncbi.nlm.nih.gov/pubmed/35849129
http://dx.doi.org/10.1093/nar/gkac582

Ejemplares similares