Cryo-EM structure of the human CST–Polα/primase complex in a recruitment state

The CST–Polα/primase complex is essential for telomere maintenance and functions to counteract resection at double-strand breaks. We report a 4.6-Å resolution cryo-EM structure of human CST–Polα/primase, captured prior to catalysis in a recruitment state stabilized by chemical cross-linking. Our str...

Descripción completa

Detalles Bibliográficos
Autores principales: Cai, Sarah W., Zinder, John C., Svetlov, Vladimir, Bush, Martin W., Nudler, Evgeny, Walz, Thomas, de Lange, Titia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371972/
https://www.ncbi.nlm.nih.gov/pubmed/35578024
http://dx.doi.org/10.1038/s41594-022-00766-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371972/
https://www.ncbi.nlm.nih.gov/pubmed/35578024
http://dx.doi.org/10.1038/s41594-022-00766-y

Ejemplares similares