A conformational switch controlling the toxicity of the prion protein

Prion infections cause conformational changes of the cellular prion protein (PrP(C)) and lead to progressive neurological impairment. Here we show that toxic, prion-mimetic ligands induce an intramolecular R208-H140 hydrogen bond (‘H-latch’), altering the flexibility of the α2–α3 and β2–α2 loops of...

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Detalles Bibliográficos
Autores principales: Frontzek, Karl, Bardelli, Marco, Senatore, Assunta, Henzi, Anna, Reimann, Regina R., Bedir, Seden, Marino, Marika, Hussain, Rohanah, Jurt, Simon, Meisl, Georg, Pedotti, Mattia, Mazzola, Federica, Siligardi, Giuliano, Zerbe, Oliver, Losa, Marco, Knowles, Tuomas, Lakkaraju, Asvin, Zhu, Caihong, Schwarz, Petra, Hornemann, Simone, Holt, Matthew G., Simonelli, Luca, Varani, Luca, Aguzzi, Adriano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371974/
https://www.ncbi.nlm.nih.gov/pubmed/35948768
http://dx.doi.org/10.1038/s41594-022-00814-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371974/
https://www.ncbi.nlm.nih.gov/pubmed/35948768
http://dx.doi.org/10.1038/s41594-022-00814-7

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