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Machine learning-based protein crystal detection for monitoring of crystallization processes enabled with large-scale synthetic data sets of photorealistic images

Since preparative chromatography is a sustainability challenge due to large amounts of consumables used in downstream processing of biomolecules, protein crystallization offers a promising alternative as a purification method. While the limited crystallizability of proteins often restricts a broad a...

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Detalles Bibliográficos
Autores principales: Bischoff, Daniel, Walla, Brigitte, Weuster-Botz, Dirk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372129/
https://www.ncbi.nlm.nih.gov/pubmed/35661232
http://dx.doi.org/10.1007/s00216-022-04101-8