Efflux dynamics of the antiseizure drug, levetiracetam, through the P-glycoprotein channel revealed by advanced comparative molecular simulations

Understanding the precise mechanistic details of the possible binding and transport of antiseizure medications (ASMs) through the P-glycoprotein (P-gp) efflux pump is essential to find strategies for the treatment of patients with epilepsy resistant to ASMs. In the present work, conventional molecul...

Descripción completa

Detalles Bibliográficos
Autores principales: Behmard, Esmaeil, Barzegari, Ebrahim, Najafipour, Sohrab, Kouhpayeh, Amin, Ghasemi, Younes, Asadi-Pooya, Ali A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372152/
https://www.ncbi.nlm.nih.gov/pubmed/35953704
http://dx.doi.org/10.1038/s41598-022-17994-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372152/
https://www.ncbi.nlm.nih.gov/pubmed/35953704
http://dx.doi.org/10.1038/s41598-022-17994-3

Ejemplares similares