Rechallenging Fluoropyrimidine-Induced Cardiotoxicity and Neurotoxicity: A Report of Two Cases

Fluoropyrimidines (FP’s) such as fluorouracil (5-FU) and capecitabine are antimetabolites widely used in many solid tumors. FPs side effects are caused mainly by a lack of dihydropyrimidine dehydrogenase (DPD) enzyme. It has been noticed that treatment with infusional regimens of 5-FU is associated...

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Autores principales: Ashish, Sethi, Raj, Moses S, Monga, Dulabh, Finley, Gene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372383/
https://www.ncbi.nlm.nih.gov/pubmed/35971344
http://dx.doi.org/10.7759/cureus.26824
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author Ashish, Sethi
Raj, Moses S
Monga, Dulabh
Finley, Gene
author_facet Ashish, Sethi
Raj, Moses S
Monga, Dulabh
Finley, Gene
author_sort Ashish, Sethi
collection PubMed
description Fluoropyrimidines (FP’s) such as fluorouracil (5-FU) and capecitabine are antimetabolites widely used in many solid tumors. FPs side effects are caused mainly by a lack of dihydropyrimidine dehydrogenase (DPD) enzyme. It has been noticed that treatment with infusional regimens of 5-FU is associated with more adverse events (AE) compared to bolus forms. Here, we report two cases of unusual side effects seen with infusional 5-FU and capecitabine and how early intervention by withholding ongoing treatment can help in preventing progression and mortality.
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spelling pubmed-93723832022-08-14 Rechallenging Fluoropyrimidine-Induced Cardiotoxicity and Neurotoxicity: A Report of Two Cases Ashish, Sethi Raj, Moses S Monga, Dulabh Finley, Gene Cureus Internal Medicine Fluoropyrimidines (FP’s) such as fluorouracil (5-FU) and capecitabine are antimetabolites widely used in many solid tumors. FPs side effects are caused mainly by a lack of dihydropyrimidine dehydrogenase (DPD) enzyme. It has been noticed that treatment with infusional regimens of 5-FU is associated with more adverse events (AE) compared to bolus forms. Here, we report two cases of unusual side effects seen with infusional 5-FU and capecitabine and how early intervention by withholding ongoing treatment can help in preventing progression and mortality. Cureus 2022-07-13 /pmc/articles/PMC9372383/ /pubmed/35971344 http://dx.doi.org/10.7759/cureus.26824 Text en Copyright © 2022, Ashish et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Ashish, Sethi
Raj, Moses S
Monga, Dulabh
Finley, Gene
Rechallenging Fluoropyrimidine-Induced Cardiotoxicity and Neurotoxicity: A Report of Two Cases
title Rechallenging Fluoropyrimidine-Induced Cardiotoxicity and Neurotoxicity: A Report of Two Cases
title_full Rechallenging Fluoropyrimidine-Induced Cardiotoxicity and Neurotoxicity: A Report of Two Cases
title_fullStr Rechallenging Fluoropyrimidine-Induced Cardiotoxicity and Neurotoxicity: A Report of Two Cases
title_full_unstemmed Rechallenging Fluoropyrimidine-Induced Cardiotoxicity and Neurotoxicity: A Report of Two Cases
title_short Rechallenging Fluoropyrimidine-Induced Cardiotoxicity and Neurotoxicity: A Report of Two Cases
title_sort rechallenging fluoropyrimidine-induced cardiotoxicity and neurotoxicity: a report of two cases
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372383/
https://www.ncbi.nlm.nih.gov/pubmed/35971344
http://dx.doi.org/10.7759/cureus.26824
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