A permeability‐ and perfusion‐based PBPK model for improved prediction of concentration‐time profiles

To improve predictions of concentration‐time (C‐t) profiles of drugs, a new physiologically based pharmacokinetic modeling framework (termed ‘PermQ’) has been developed. This model includes permeability into and out of capillaries, cell membranes, and intracellular lipids. New modeling components in...

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Detalles Bibliográficos
Autores principales: Korzekwa, Ken, Radice, Casey, Nagar, Swati
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372417/
https://www.ncbi.nlm.nih.gov/pubmed/35588513
http://dx.doi.org/10.1111/cts.13314

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372417/
https://www.ncbi.nlm.nih.gov/pubmed/35588513
http://dx.doi.org/10.1111/cts.13314

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