Concurrent inhibition of FAK/SRC and MEK overcomes MEK inhibitor resistance in Neurofibromatosis Type I related malignant peripheral nerve sheath tumors

Malignant peripheral nerve sheath tumors (MPNST) are aggressive soft-tissue sarcomas which lack effective drugs. Loss of the RAS GTPase-activating protein NF1 and subsequent overactivation of mitogen-activated protein kinase kinase (MAPK) signaling exist nearly uniformly in MPNST, making MAPK inhibi...

Descripción completa

Detalles Bibliográficos
Autores principales: Gu, Yihui, Wei, Chengjiang, Chung, Manhon, Li, Haibo, Guo, Zizhen, Long, Manmei, Li, Yuehua, Wang, Wei, Aimaier, Rehanguli, Li, Qingfeng, Wang, Zhichao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372505/
https://www.ncbi.nlm.nih.gov/pubmed/35965583
http://dx.doi.org/10.3389/fonc.2022.910505

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372505/
https://www.ncbi.nlm.nih.gov/pubmed/35965583
http://dx.doi.org/10.3389/fonc.2022.910505

Ejemplares similares