Autoantibodies against NMDAR subunit NR1 disappear from blood upon anesthesia

Anesthetics penetrate the blood-brain-barrier (BBB) and - as confirmed preclinically – transiently disrupt it. An analogous consequence in humans has remained unproven. In mice, we previously reported that upon BBB dysfunction, the brain acts as ‘immunoprecipitator’ of autoantibodies against N-methy...

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Detalles Bibliográficos
Autores principales: Teller, Johannes, Jung, Carolin, Wilke, Justus B.H., Schimmelpfennig, Svea-Dorothée, Hindermann, Martin, Hinken, Lukas, Gabriel, Maria M., Fegbeutel, Christine, Schäfer, Andreas, Laser, Hans, Lichtinghagen, Ralf, Worthmann, Hans, Weissenborn, Karin, Ehrenreich, Hannelore
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372600/
https://www.ncbi.nlm.nih.gov/pubmed/35965838
http://dx.doi.org/10.1016/j.bbih.2022.100494
Descripción
Sumario:Anesthetics penetrate the blood-brain-barrier (BBB) and - as confirmed preclinically – transiently disrupt it. An analogous consequence in humans has remained unproven. In mice, we previously reported that upon BBB dysfunction, the brain acts as ‘immunoprecipitator’ of autoantibodies against N-methyl-D-aspartate-receptor subunit-NR1 (NMDAR1-AB). We thus hypothesized that during human anesthesia, pre-existing NMDAR1-AB will specifically bind to brain. Screening of N = 270 subjects undergoing general anesthesia during cardiac surgery for serum NMDAR1-AB revealed N = 25 NMDAR1-AB seropositives. Only N = 14 remained positive post-surgery. No changes in albumin, thyroglobulin or CRP were associated with reduction of serum NMDAR1-AB. Thus, upon anesthesia, BBB opening likely occurs also in humans.

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