The airway smooth muscle sodium/calcium exchanger NCLX is critical for airway remodeling and hyperresponsiveness in asthma

The structural changes of airway smooth muscle (ASM) that characterize airway remodeling (AR) are crucial to the pathogenesis of asthma. During AR, ASM cells dedifferentiate from a quiescent to a proliferative, migratory, and secretory phenotype. Calcium (Ca(2+)) is a ubiquitous second messenger tha...

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Detalles Bibliográficos
Autores principales: Johnson, Martin T., Benson, J. Cory, Pathak, Trayambak, Xin, Ping, McKernan, Abagail S., Emrich, Scott M., Yoast, Ryan E., Walter, Vonn, Straub, Adam C., Trebak, Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372629/
https://www.ncbi.nlm.nih.gov/pubmed/35841929
http://dx.doi.org/10.1016/j.jbc.2022.102259

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372629/
https://www.ncbi.nlm.nih.gov/pubmed/35841929
http://dx.doi.org/10.1016/j.jbc.2022.102259

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