Targeting the lung epithelium after intravenous delivery by directed evolution of underexplored sites on the AAV capsid

Advances in adeno-associated virus (AAV) engineering have provided exciting new tools for research and potential solutions for gene therapy. However, the lung has not received the same tailored engineering as other major targets of debilitating genetic disorders. To address this, here we engineered...

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Detalles Bibliográficos
Autores principales: Goertsen, David, Goeden, Nick, Flytzanis, Nicholas C., Gradinaru, Viviana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372736/
https://www.ncbi.nlm.nih.gov/pubmed/35990749
http://dx.doi.org/10.1016/j.omtm.2022.07.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372736/
https://www.ncbi.nlm.nih.gov/pubmed/35990749
http://dx.doi.org/10.1016/j.omtm.2022.07.010

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