Proximity-based labeling reveals DNA damage–induced phosphorylation of fused in sarcoma (FUS) causes distinct changes in the FUS protein interactome

Accumulation of cytoplasmic inclusions containing fused in sarcoma (FUS), an RNA/DNA-binding protein, is a common hallmark of frontotemporal lobar degeneration and amyotrophic lateral sclerosis neuropathology. We have previously shown that DNA damage can trigger the cytoplasmic accumulation of N-ter...

Descripción completa

Detalles Bibliográficos
Autores principales: Johnson, Michelle A., Nuckols, Thomas A., Merino, Paola, Bagchi, Pritha, Nandy, Srijita, Root, Jessica, Taylor, Georgia, Seyfried, Nicholas T., Kukar, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372748/
https://www.ncbi.nlm.nih.gov/pubmed/35709984
http://dx.doi.org/10.1016/j.jbc.2022.102135

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372748/
https://www.ncbi.nlm.nih.gov/pubmed/35709984
http://dx.doi.org/10.1016/j.jbc.2022.102135

Ejemplares similares