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Proximity-based labeling reveals DNA damage–induced phosphorylation of fused in sarcoma (FUS) causes distinct changes in the FUS protein interactome

Accumulation of cytoplasmic inclusions containing fused in sarcoma (FUS), an RNA/DNA-binding protein, is a common hallmark of frontotemporal lobar degeneration and amyotrophic lateral sclerosis neuropathology. We have previously shown that DNA damage can trigger the cytoplasmic accumulation of N-ter...

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Detalles Bibliográficos
Autores principales:	Johnson, Michelle A., Nuckols, Thomas A., Merino, Paola, Bagchi, Pritha, Nandy, Srijita, Root, Jessica, Taylor, Georgia, Seyfried, Nicholas T., Kukar, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372748/ https://www.ncbi.nlm.nih.gov/pubmed/35709984 http://dx.doi.org/10.1016/j.jbc.2022.102135

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