The human EF1a promoter does not provide expression of the transgene in mice

In this work, we set out to create mice susceptible to the SARS-CoV-2 coronavirus. To ensure the ubiquitous expression of the human ACE2 gene we used the human EF1a promoter. Using pronuclear microinjection of the transgene construct, we obtained six founders with the insertion of the EF1a-hACE2 tra...

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Detalles Bibliográficos
Autores principales: Battulin, Nariman, Korablev, Alexey, Ryzhkova, Anastasia, Smirnov, Alexander, Kabirova, Evelyn, Khabarova, Anna, Lagunov, Timofey, Serova, Irina, Serov, Oleg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372930/
https://www.ncbi.nlm.nih.gov/pubmed/35960480
http://dx.doi.org/10.1007/s11248-022-00319-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372930/
https://www.ncbi.nlm.nih.gov/pubmed/35960480
http://dx.doi.org/10.1007/s11248-022-00319-5

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