Editing TINF2 as a potential therapeutic approach to restore telomere length in dyskeratosis congenita

Mutations in the TINF2 gene, encoding the shelterin protein TIN2, cause telomere shortening and the inherited bone marrow (BM) failure syndrome dyskeratosis congenita (DC). A lack of suitable model systems limits the mechanistic understanding of telomere shortening in the stem cells and thus hinders...

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Detalles Bibliográficos
Autores principales: Choo, Seunga, Lorbeer, Franziska K., Regalado, Samuel G., Short, Sarah B., Wu, Shannon, Rieser, Gabrielle, Bertuch, Alison A., Hockemeyer, Dirk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2022
Materias:
Hematopoiesis and Stem Cells
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9373014/
https://www.ncbi.nlm.nih.gov/pubmed/35421215
http://dx.doi.org/10.1182/blood.2021013750

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9373014/
https://www.ncbi.nlm.nih.gov/pubmed/35421215
http://dx.doi.org/10.1182/blood.2021013750

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